Preparation of the first isothiazolinylidene complexes of Fe, W and Au

M.Sc.Please refer to full text to view abstract

A novel approach to steganone analogues via metal-mediated cyclisations

Transition metal mediated cyclisation reactions are utilised in the synthesis of analogues of the naturally-occurring antileukemic bisbenzocyclooctadiene lignan, steganone. The first approach involves the metal-mediated [2+2+2] cycloaddition of a rationally designed linear 1,9-diyne with a hindered alkyne. This diyne is formed via a convergent synthetic sequence starting from 3,4,5-trimethoxybenzaldehyde and paraconic acid. The cyclisation reaction proceeds diastereospecifically to give the atropisomer relevant to the natural product. The cycloadduct thus formed has been elaborated to give several novel analogues of steganone. The reaction of this diyne and a model diyne with a chromium carbenoid complex is investigated. This methodology is found to be unsuitable to the formation of this ring system. A family of macrocycles is postulated, in which one aryl ring present in steganone is replaced with an enediyne moiety. It is suggested these will furnish steganone analogues after Bergman cycloaromatisation. A number of approaches to this class of compound are described. Several advanced linear macrocycle precursors are synthesised, and their metal-mediated cyclisation reactions are investigated. The final approach to steganone analogues involves cascade carbopalladation of a linear bromoenyne. This bromoenyne is synthesised via a similar synthetic sequence to the diyne previously mentioned. The co-cyclisation of this bromoenyne with trimethylsilylethyne under conditions of palladium catalysis is investigated

Annular elastolytic giant cell granuloma treated with topical pimecrolimus.

4openopenErrichetti E; Stinco G; Avellini C; Patrone P.Errichetti, E; Stinco, Giuseppe; Avellini, C; Patrone, Pasqual

Synthesis of polysubstituted-1, 4-quinones and allylsilanes via alkenyl Fischer carbene complexes.

by Chi-Ching Mak.Thesis (M.Phil.)--Chinese University of Hong Kong, 1993.Includes bibliographical references (leaves 65-70).Acknowledgement --- p.iAbbreviation --- p.iiList of spectra --- p.iiiContents --- p.ivAbstract --- p.vChapter Part One: --- "Synthesis of Poly substituted-1,4-Quinones"Chapter 1.1 --- IntroductionChapter 1.2 --- Results and discussion --- p.9-16Chapter 1.3 --- Conclusion --- p.17Chapter Part Two: --- Synthesis of AllylsilanesChapter 2.1 --- Introduction --- p.18-25Chapter 2.2 --- Results and discussion --- p.26-34Chapter 2.3 --- Conclusion --- p.35Experimental Section --- p.36-64References --- p.65-70Spectra --- p.71-8

Histo-blood group glycans in the context of personalized medicine

General significance: Histo-blood group glycans have a unique linking position in the complex network of genes, oncodevelopmental biological processes, and disease mechanisms. Thus, they are highly promising targets for novel approaches in the field of personalized medicine. This article is part of a Special Issue entitled "Glycans in personalised medicine" Guest Editor: Professor Gordan Lauc. (C) 2015 Elsevier B.V. All rights reserved.Proteomic